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LSD (Lysergic Acid Diethylamide): Overview and Key Details

Lysergic Acid Diethylamide, commonly known as LSD or “acid,” is a potent hallucinogenic compound. First synthesized in 1938 by Swiss chemist Dr. Albert Hofmann, LSD is derived from ergot, a fungus that grows on rye and other grains. Known for its profound effects on perception, mood, and cognition, LSD is a Schedule I controlled substance in many countries, indicating its potential for abuse and lack of accepted medical use.

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How Does LSD Work?

LSD exerts its effects by interacting with serotonin receptors in the brain, particularly the 5-HT2A receptor, which influences mood, sensory perception, and cognition. When ingested, LSD induces an altered state of consciousness, often referred to as a “trip.” These experiences can range from euphoria and heightened sensory awareness to intense introspection or, in some cases, anxiety and paranoia.

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Effects of LSD

1. Psychological Effects:
   • Altered perception of time and space.
   • Enhanced or distorted sensory experiences (visual and auditory).
   • Heightened emotions, which can lead to euphoria or anxiety.
2. Physical Effects:
   • Increased heart rate and blood pressure.
   • Dilated pupils.
   • Sweating or chills.
3. Long-term Impacts:
   While LSD is not considered physically addictive, frequent use can lead to psychological dependence. Users may also experience flashbacks, known as Hallucinogen Persisting Perception Disorder (HPPD).

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Applications and Controversies

Historically, LSD was studied for potential therapeutic applications in treating anxiety, depression, and PTSD. Recent research into psychedelics has revived interest in LSD as a potential treatment under controlled, clinical settings. However, its recreational use and association with counterculture movements have contributed to its controversial status.

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Specifications

• Chemical Formula: C20H25N3O
• Molecular Weight: 323.44 g/mol
• Form: Colorless, odorless crystalline substance, often distributed on blotter paper.
• Potency: Effective at extremely low doses (measured in micrograms).

1P-LSD also known as 1-propionyl-LSD and 1-propionyl-lysergic acid diethylamide, is the 1-propionyl analog of LSD.

IUPAC: 1-propionyl-lysergic acid diethylamide
CAS#: N/A
Molecular Mass: 379.45926g/mol
Molecular Formula: C23H29N3O2
1P-LSD Pellets For Sale

1p-LSD, short for 1 Propionyl Lysergic Acid Diethylamide is the hallucinogenic, psychedelic drug that belongs to the family of lysergamide.

Surprisingly it is structurally similar to LSD and ALD 52 which suggests it has an identical effect profile as well. With the lack of research related to this substance, every argument related to the pharmacology of this drug is completely according to its structure and the subjective effect that are not different from other such lysergamides.
1P-LSD Chemistry

According to its molecular structure, it belongs to the lysergamide family. It is quite analogous to LSD, and it has been named for its propionyl group that is bound to the nitrogen of the polycyclic indole group. The propionyl consists of a carbonyl chain that is bound to an amino group. 1p-LSD contains a polycyclic group that features the bicyclic Hexahydro indole bound to its quinolone bicyclic group. At carbon 9 of quinoline, the n-diethyl carboxamide becomes bound.
1P-LSD Pharmacology

It acts as the partial agonist of 5 HT2A. Psychedelic effects come from efficacy at 5HT2A receptors. The role of such interactions and how these result in psychedelic experience always remain elusive.

Moreover, it has been theorized that 1p-LSD is a prodrug to LS. It shows only 35% potency of LDS in mice. The LSD is detected with the help of LC-MS when the 1p-LSD is incubated in Human Serum. This means that 1p-LSD doesn’t only act as a prodrug for LSD but also, it directly acts as a serotonin receptor against its very own rights.
1P-LSD Subjective Effects

The subjective effects of 1p-LSD are similar to those structurally related to it. The differences are minuscule that is negligible and virtually indistinguishable from each other. As compared to other psychedelics which include LS and Psilocin, the 1p-LSD proves to be even more stimulating and fast-paced when it comes to a specific type of its physical and cognitive effects. The effects are listed below that is based on the subjective effects index and personal experience of some subjects. The listed effects rarely occur and only once. However if the dosage is heavy, it can lead to severe cases.

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Features

1. Powerful Hallucinogen: Known for its strong and long-lasting effects, lasting up to 12 hours.
2. Non-Addictive: Does not cause physical dependence.
3. Cultural Impact: Central to the 1960s counterculture movement and ongoing psychedelic research.